Selection of non-P-glycoprotein mediated high-level etoposide resistant cell lines by adriamycin with P-gp inhibitors
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چکیده
منابع مشابه
P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.
PURPOSE Despite the extensive use of etoposide for the treatment of different malignant neoplasms, its main pharmacokinetic determinants are not completely defined. We aimed to study the impact of P-glycoprotein (P-gp/ABCB1) and the multidrug resistance proteins ABCC2 (MRP2) and ABCC3 (MRP3) on the pharmacokinetics of etoposide. EXPERIMENTAL DESIGN Abcb1a/1b(-/-), Abcc2(-/-), Abcc3(-/-), Abcb...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2006
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.28.3.747